|About this Abstract
||Materials Science & Technology 2012
||MS&T'12 Poster Session
||A8: Preparation and Characterization of Injectable Bone-Filling Chitosan-Silicate Hydrogels with Nano-Size Hydroxyapatite
||Yuri Nakamura, Yuki Shirosaki, Satoshi Hayakawa, Akiyoshi Osaka, Eiji Fujii, Koji Kawabata
|On-Site Speaker (Planned)
Injectable bone filler systems are necessary for minimal invasive surgery of restoring bone defects. Bone fillers, composed of micro-granules and hydrogels, are studied extensively, yet those hydrogels take a long time for gelation. The hybrid hydrogels in the ternary system of chitosan, γ-glycidoxypropyltrimethoxysilane (GPTMS), and β-glycerophosphate (β-GP) are controllable in the gelation time and show good cell compatibility. Since hydroxyapatite (HAp) naturally showed good bone-compatibility to favor bone defect healing, this study examined the effects of the incorporation of nano-size HAp or dicalcium phosphate into the hybrid hydrogels. With an appropriate range of the mass ratio nano-HAp/hydrogels, the gelation time was reduced to less than 20 min, and putty-like plasticity was attained. Moreover, the osteoblastic cells (MG63) were attached better on the present hybrid hydrogels with nano-HAp.
||Definite: A CD-only volume