|About this Abstract
||2016 TMS Annual Meeting & Exhibition
||Advanced Materials in Dental and Orthopedic Applications
||Polymeric Coating for Optimization of Drug Release from Drug-Loaded Surfaces
||Azhang Hamlekhan, Sweetu Patel, Tolou Shokuhfar
|On-Site Speaker (Planned)
Titanium and its alloys are widely used for fabrication of dental and orthopedic implants. In order to improve surface biocompatibility of titanium implants, it is anodized to form titanium oxide nanotubes on its surface. Previous studies show that nanotubes stimulate cellular activity in comparison with conventional smooth surface of titanium. In addition, they act as careers that can deliver drug locally to avascular tissue that remains after surgery. Although nanotubes are successfully loaded with various types of drugs, controlling rate of drug release needs further investigation. In this study, gelatin is used to inhibit sudden release of drug from nanotubes during initial phase of drug release. Our results suggest that gelatin is gradually degraded in aqueous environment, which results in slow release of loaded drug.
||Planned: A print-only volume