|About this Abstract
||2017 TMS Annual Meeting & Exhibition
||Biological Materials Science
||Engineering Antibacterial and Anti-Biofilm Surfaces
||Dalal Asker, Benjamin Hatton
|On-Site Speaker (Planned)
Implanted medical devices are at significant risk of developing bacterial biofilm-associated infections and 60% of hospital-acquired infections are due to such biofilm formation. Herein we will present three complementary approaches to engineering surfaces to prevent bacterial attachment and biofilm formation, from highly strain specific to very general. Recently we have immobilized an glycoside hydrolase enzyme which rapidly degrades the extracellular polysaccharide (Psl) of P. aeruginosa and interferes with biofilm development. In a second approach, we have incorporated a common antimicrobial drug with surfactant-like properties into supramolecular drug/silica mesostructures through molecular self-assembly. Finally, we have demonstrated that PDMS elastomers infused with non-crosslinked PDMS polymer, can exhibit self-lubricated properties as a ‘slippery liquid infused porous surface’ (SLIPS), similar to many natural non-adhesive surfaces. These layers show a dynamic and continuous migration of the oil to the elastomer surface, which maintains a consistent surface liquid layer as a barrier to bacterial attachment.
||Planned: Supplemental Proceedings volume