Metallic glasses boast high strength, but their low ductility has been a major concern. Taking a structural perspective and citing selected examples, in this talk we advocate purposely enhanced structural inhomogeneities, in an otherwise compositionally uniform and single-phase amorphous alloy, to promote distributed plastic flow. Four current tactics (the 4R’s) to improve deformability are highlighted, from the standpoint of structural heterogeneities that can be tailored in the monolithic glassy state. These include the retention of highly rejuvenated glass structures, coupled with restrained propagation and even nucleation of shear bands, and possibly relocation when necessary to compositions where the internal structures are amenable to being tuned to proliferate GUMs (geometrically unfavored motifs). These strategies point the way to improvements in plasticity and toughness, and occasionally even tensile ductility with necking that is unusual for glasses at room temperature. (See our review in Mater. Today published online April 30, 2016).