|About this Abstract
||Materials Science & Technology 2012
||Bioinspired Materials Engineering
||Biohybrids from Nucleic Acids and Collagen Assemblies towards Bioresponsive Silica Materials
||Carole Aime, Thibaud Coradin
|On-Site Speaker (Planned)
Biomolecules are relevant candidates to be incorporated into hybrid materials due to their biological functions that rely mainly on self-assembly and specific molecular recognition. Our strategy combines biomolecules and silica particles as inorganic counterpart, to take advantage of both components in terms of self-assembly and materials structuration. We use an original approach through the chemical modification of silica particles surface to graft either nucleic acids or collagen triple helices. This provides us with ubiquitous building blocks, which are intrinsically hybrid. In so doing we can tune the structure and number of grafted biomolecules. We could control the hierarchical assembly of bio-hybrid building blocks to open the door towards a new generation of hybrid materials. In particular, while the use of nucleic acid self-assemblies triggers the organization of inorganic particles, grafting collagen at the particle surface allows directing fibrils assembly to engineer bioresponsive systems having improved mechanical and chemical stability.
||Definite: A CD-only volume