|About this Abstract
||2017 TMS Annual Meeting & Exhibition
||Pan American Materials Congress: Advanced Biomaterials
||Comparative Analysis of Neural Cell Behaviour on Carbon Nanofiller Reinforced Polymeric Substrates
||Pallavi Gupta, Murali Kumaraswamy, Partha Roy, Debrupa Lahiri
|On-Site Speaker (Planned)
Since last decade, carbon nanomaterials such as carbon nanotubes (CNTs) and graphene nanoplatelets (GNPs) have gained remarkable popularity as substrate for neural tissue engineering. It has already been demonstrated that carbon nanomaterials possess ability to guide neurites to extend along the direction of alignment, resembling native hierarchy of neural tissue. In this study, HT-22 hippocampal neurons were used to investigate interactions of neurons with carbon nanofillers reinforced casted chitosan scaffolds. It was confirmed that the neurons show shape dependency on CNT and GNP reinforced scaffold, owing to electrical conductivity of scaffolds and shape of reinforced carbon nanofillers. Tensile properties and electrical conductivities of fabricated scaffolds were also characterized. Further, the effect of CNT and GNP alignment inside chitosan scaffold was also assessed on mechanical, electrical and biological activity of the scaffolds. Results prove that the carbon nanofiller reinforced chitosan scaffolds provide new guidelines for designing the well-defined neuronal network architecture.
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