| About this Abstract |
| Meeting |
Materials Science & Technology 2011
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
Scaffolds to Guide Stem Cells for Bone and Dentin Regeneration |
| Author(s) |
Peter X Ma |
| On-Site Speaker (Planned) |
Peter X Ma |
| Abstract Scope |
ScBone and dentin tissue loss remains a major clinical challenge. Regenerative medicine aims for biological restoration of lost or diseased tissues. Our lab develops biomimetic polymer scaffolds that recapitulate certain advantageous features of the natural extracellular-matrices (ECM) and impart engineering design to facilitate tissue regeneration. Novel phase separation techniques have been developed in our laboratory to create biodegradable ECM-mimicking nanofibrous scaffolds. Porous network design and computer assisted body-part shape creation allows for patient specific scaffold fabrication. We also develop novel polymer/calcium phosphate composite scaffolds to facilitate mineralized tissue regeneration. In addition, we design novel polymers and self-assembled nanospheres for controlled biomolecule delivery in the scaffolds to recapitulate certain developmental programs. Enhanced bone and dentin regeneration outcomes by various stem cells demonstrate the excitement of the biomimetic materials in regenerative medicine. |
| Proceedings Inclusion? |
Undecided |